MTHFR / Methylation
Methylation support and genetic variant management for those with MTHFR gene mutations affecting folate processing and overall health.
What is MTHFR / Methylation Disease?
MTHFR is a form of an autoimmune disease. It is actually the name of an enzyme — methylenetetrahydrofolate reductase — that adds a methyl group to folic acid so the body can process it. It is also responsible for properly processing vitamin B9 and converts homocysteine into methionine, which regulates the body's metabolism, assists with muscle growth, and plays a role in ridding the body of toxins.
People with an MTHFR gene mutation have a seriously reduced ability to convert folic acid or folate into a form the body can process. Although the name sounds concerning, with proper care and management the condition shouldn't stop anyone from living a full life.
Genes are made up of DNA — the directions for each cell. Every person gets two copies of each gene, one from each parent. These are given in pairs called alleles. If someone has a mismatched pair of genes, it can result in severe cases of developmental delays and defects.
What MTHFR Does in the Body
Understanding Methylation
Methylation is a fundamental biochemical process that affects virtually every system in your body.
What is Methylation?
Methylation is when one molecule passes a methyl group to another molecule — something that is constantly happening in your body millions of times a minute. It is essential for gene expression, detoxification, and cellular repair.
What Happens When Methylation Fails?
When gene sequences that should be off remain on (or vice versa), healthy cells can continue to replicate uncontrollably, forming tumors. This is why MTHFR SNP mutations increase the risk of developing cancer.
The Role of Homocysteine
MTHFR mutations lead to elevated homocysteine levels, which are associated with intravascular inflammation and a high number of the medical problems linked to the condition.
Associated Health Risks
The MTHFR C677T SNP is associated with increased risk of a number of serious conditions. Early identification and proper management are essential.
Common Symptoms of MTHFR Mutation
A person who has the MTHFR gene mutation usually suffers from a range of symptoms due to the gene's involvement in so many bodily systems:
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